<原著>諸種平滑筋収縮薬の作用におよぼすcadmiumの影響

概要

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Using the isolated seminal vesicles from guinea pig, the influence of Cd on the actions of the various smooth muscle contractile agents (K, acetylcholine, noradrenaline (NA), Ca and Ba) was investigated.1. The low concentration of Cd inhibited selectively the contractions by K and Ca, and the high one also inhibited the contractions by ACh, NA and Ba in addition.2. The effect of Cd was inhibited by the thiol compounds.3. The inhibitory effects of Cd on the actions of NA and ACh were almost equal.4. By summarizing the above-mentioned results, the following suggestions were obtained. 1) The low concentration of Cd inhibits the Ca infux and the high one also inhibits the Ca release in addition. 2) Cd inhibits the contraction by acting on sulfhydryl group. 3) The inhibitory effect of Cd on the receptors is non-specific.
近畿大学の論文
1977-06-25