<血行動態に関する研究>WKYならびにSHRSPの摘出腎動脈におけるアセチルコリンによる内皮細胞依存性収縮反応

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We examined the contractile responses to acetylcholine (ACh) in isolated renal artery rings obtained from WKY and SHRSP at 3 and 6 months of age. ACh caused a transient contraction in endothelium-intact renal arteries from WKY and SHRSP. ACh-induced contraction was abolished by removal of the endothelium, and was augmented by pretreatment with N^G-nitro-L-arginine (NOARG) in both groups. Indomethacin completely inhibited ACh-induced contraction in NOARG-treated arteries of WKY and SHRSP. Contraction induced by ACh was significantly smaller in SHRSP at 3 and 6 months of age than in age-matched WKY. ACh-induced endothelium-dependent relaxation in renal arteries precontracted with phenylephrine was decreased in SHRSP at 3 and 6 months of age when compared to age-matched WKY. Relaxation induced by ACh was inhibited by NOARG in both groups. These results suggest that ACh produces both contractile responses mediated by cyclooxygenase products and relaxation responses mediated by nitric oxide in an endothelium-dependent manner, and that these responses were impaired in SHRSP.
近畿大学の論文
1994-12-30