<血行動態に関する研究>SHRSPの摘出腸間膜動脈におけるカルシトニン遺伝子関連ペプチドの弛緩作用

概要

論文の詳細を見る
Relaxation response to calcitonin gene-related peptide (CGRP) on superior mesenteric arteries was markedly enhanced in SHRSP compared to that in WKY. CGRP-induced relaxation was not affected by mechanical removal of the endothelium, or by pretreatment with N^G-nitro-L-arginine (NO synthase inhibitor) in either group. Glibenclamide (K-ATP channel blocker) had no influence on CGRP-induced relaxation in either SHRSP or WKY. There were no significant differences between the two groups in the relaxations generated by forskolin, dibutyryl cyclic AMP, and 3-isobutyl-1-methylxanthine. These findings indicate that the increased reactivity to CGRP shown in SHRSP is the results of up-regulation of CGRP receptors in the smooth muscles of the superior mesenteric arteries.
近畿大学の論文
1994-12-30