<原著>モルモット摘出精管におけるATPの収縮機序, およびこれにおよぼす外液NaおよびKの影響, とくにCaとの関連

概要

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Using the strips of vas deferens from guinea-pigs, the contractile mechanism of ATP and the effects of the modified contents of Na and K in the bathing solution (BS) on the action of ATP were investigated in relation to the mobilization of Ca. 1. Shape of the contractile response to ATP consisted of phasic contractions without tonic contractions. The contractile response to ATP was not affected by a 5 min exposure to Ca-free BS or metabolic inhibitors, which suggests that the ATP-induced contraction is elicited by the release of Ca from the storage sites, without the participation of Ca influx. 2. ATP produces the release of Ca from the store where Ca is most easily released. 3. After a 5 min exposure to Na-deficient BS, the contractile response to ATP was potentiated, which suggests that the release of Ca by ATP is accelerated in Na-deficient BS. However, after a 30 min exposure, that was inhibited, which suggests that the release of Ca by ATP is then inhibited. 4. After a 60 min exposure to K-free BS, the contractile response to ATP was reduced, which suggests that the release of Ca by ATP is inhibited.
近畿大学の論文
1976-12-28