平滑筋収縮薬の作用におよぼすNa減量栄養液の影響(ラット門脈における実験)(A 基礎的研究)(II 予防および治療)

概要

論文の詳細を見る
By using the isolated portal vein of rats, the effects of Na decreased medium on the responses to the smooth muscle contractile agents, K, acetylcholine, noradrenaline and Ba, were investigated and the following results were obtained. 1. The responses to the contractile agents tested decreased in accordance with the degree of decrease of sodium in the medium. 2. In the Na 3/4 medium, the contraction by K was inhibited more remarkably compared with the contractions by the other agents, and in the Na 1/2 medium, the contractions by acetylcholine and K were inhibited more strongly compared with the contractions by the other agents. In the 1/4 Na medium, the contraction by Ba was inhibited more remarkably compared with the contractions by the other agents. 3. The remarkable difference was not found between the response to acetylcholine and that to noradrenaline in the Na decreased medium. 4. From the results stated above, the following suggestions were obtained : (1) the inhibition of the contractions by the agents in the Na decreased medium is due to the inhibition of Ca transport in the large part and the disturbanceof excitability of receptors in the small part, (2) the decreased Na in medium does not specifically inhibit the excitability of sympathetic α-receptor.
近畿大学の論文
1980-09-25