<基礎的研究発生病理>SHRSPの摘出腎動脈におけるカルシトニン遺伝子関連ペプチドの弛緩作用

概要

論文の詳細を見る
Relaxant response to calcitonin gene-related peptide (CGRP) on renal arteries was markedly increased in SHRSP when compared to WKY. CGRP-induced relaxation was not affected by mechanical removal of the endothelium in either group. Although the enhanced CGRP-induced relaxation was found in SHR, the degree of relaxation was greater in SHRSP than in SHR. The relaxation induced by forskolin, dibutyryl cAMP, and 3-isobutyl-1-methylxanthine did not differ between WKY and SHRSP. The CGRP-induced relaxation in both WKY and SHRSP was not inhibited by pretreatment with glibenclamide. Thus, one possible explanation for the enhanced CGRP-induced relaxation found in the renal artery of SHRSP is the increased sensitivity of CGRP receptors.
近畿大学の論文
1993-12-30