<予防および治療>カルシウム拮抗薬NB-818の意識下SHRSP血行動態に与える影響

概要

論文の詳細を見る
The acute hemodymamic effects of NB-818 were studied in conscious 6-month-old strokeprone spontaneously hypertensive rats (SHRSP). The radioactive microsphere technique was used to estimate the regional blood flow and cardiac output after intravenous injection of NB-818 30 nmoles/kg or vehicle. Total peripheral resistance decreased greatly accompanied by a large fall in mean arterial pressure in the NB-818 treated group compared with the vehicle group. However, the cardiac output and the heart rate did not change significantly after the NB-818 treatment. The regional blood flow slightly increased in the heart, kidneys and gastrointestinal tract (GIT), but the brain blood flow was not changed at all. Regional resistance decreased significantly in the heart, kidneys and GIT, and slightly in the brain in the NB-818 treated group compared with the vehicle group. These results indicate that NB-818 may be favorable for the treatment of cardio-cerebral diseases involved in hypertension.
近畿大学の論文
1989-12-30