Detoxification Metabolism of o-Dinitrobenzene by the Yeast Issatchenkia orientalis(Microbiology & Fermentation Industry)

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概要

• 論文の詳細を見る

• Culture medium containing 200μm o-dinitrobenzene suppressed cell growth of Issatchenkia orientalis for about 24 hr and after a lag phase, the cells began to increase with concomitant metabolism of o-dinitrobenzene by glutathione conjugation. The resulting glutathione conjugate, S-(2-nitrophenyl)glutathione, was further enzymatically metabolized and released into the growth medium. The final metabolite was identified as S-(2-nitrophenyl)cysteine by comparison with the authentic compound on HPLC. In the presence of o-dinitrobenzene, intracellular glutathione was not detected in the early log phase, but it began to accumulate after o-dinitrobenzene was metabolized. S-(2-nitrophenyl)glutathione and S-(2-nitrophenyl)cysteine, both chemically synthesized, did not suppress cell growth. These results suggest that there is a glutathione-related detoxification system in the yeast I. orientalis.

• 社団法人日本農芸化学会の論文
• 1991-04-23

著者

• TAMAKI HISANORI

  Department of Food Science and Technology, Kyoto University

• KUMAGAI HIDEHIKO

  Department of Food Science and Technology, Kyoto University

• TOCHIKURA TATSUROKURO

  Department of Food Science and Technology, Kyoto University

• Kumagai H

  Kyoto Univ.

• Kumagai Hidehiko

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Kumagai Hidehiko

  Faculty Of Agriculture Kyoto University

• SHIMADA Yoshimi

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• KASHIMA Takanori

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• OBATA Hiroshi

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• KIM Chul-Sa

  Pesticide Research Institute, Kyoto University

• UENO Tamio

  Pesticide Research Institute, Kyoto University

• Kumagai H

  Research Institute For Bioresources And Biotechnology Ishikawa Prefectural University

• Tamaki H

  Kyoto Univ. Kyoto Jpn

• Tamaki Hisanori

  Division Of Integrated Life Sciences Graduate School Of Biostudies Kyoto University

• Tamaki Hisanori

  Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University

• Tochikura Tatsurokuro

  Faculty Of Home Economics Kobe Women's University

• Tochikura Tatsurokuro

  Department Of Food Science And Technology Kyoto Unicersity

• Tochikura Tatsurokuro

  Department Of Agricultural Chemistry Kyoto University

• Obata Hiroshi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Kim Chul-sa

  Pesticide Research Institute Kyoto University

• Ueno Tamio

  Pesticide Research Institute Kyoto University

• Tachiki Takashi

  Department Of Chemistry Ritsumeikan University

• Kumagai H

  Department Of Agricultural Chemistry The University Of Tokyo

• Tachiki T

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Shimada Yoshimi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Tachiki Takashi

  Faculty Of Home Economics Kobe Women's University

• Tachiki Tkashi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Kashima Takanori

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Ueno T

  Tokyo National Coll. Technology Tokyo Jpn

• Tamaki Hisanori

  Industrial Research Institute Of Ishikawa

• Obata Hiroshi

  Department of Chemistry Faculty of Science Tohoku University

• KUMAGAI Hidehiko

  Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University

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