清酒火落菌の栄養物質と其の拮抗物質に関する研究 : (第12報)ピリミヂン拮抗物質に依る発育の阻害

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Five substituted uracil derivatives were examined on their ability to inhibit the growth of Hiochi-kin in a uracil-omitted synthetic medium. Among these derivatives, 5-nitrouracil was most potent, and inhibited the growth of Hiochi-kin T102 and T107 at a concentration of 2 μg/ml. 2-thiouracil inhibited the growth of strain T102,but more slightly that of strain T107. The inhibitions by 5-hydroxy and 5-aminouracil were moderate. 5-bromo-uracil did not inhibit the growth even at a concentration of 100 μg/ml.The inhibittion of the gtrowth by these antagonists were reversed by pyrimidine mixtures but not by purines. The effect of 2-thiourocil was reversed by uracil, and that of 5-nitrouracil by thymine and thymidine. At the presence of 0.1 μg/ml of thymine, 100 μg/ml of 5-nitro-uracil was required for the complete inhibition of the growth of Hiochi-kin.
社団法人日本生物工学会の論文
1958-01-15