連続醗酵によるグルタミン酸生産に関する研究 : (第3報) 細胞活性の分布とその連続醗酵系設計への応用

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A method to design the production stages of the multiple stage continuous fermentation was investigated. This method has two concepts as its base. One is the theory of residence time distribution function, which developed in the field of continuous catalytic reaction studies, and is shown in equations (2) and (2'). The other new concept intruduced is the activity function of cell population in the production stages, which is given as a function of its residence time-this function is shown in equation (3), and can be determined experimentally by the replacement culture.Combining those two bases, we can obtain the activity distribution function of the cell population in the production stages. This function can be shown as follows : df/(dt)A(t) dt By the graphical integration of the activity distribution, according to equations (4) and (6), as illustrated in Fig. 3,the "Mean fermentation rate" and the "Mean completion of fermentation or Mean utilization of cell population activity" can be theoretically predicted as functions of mean residence time and vessel numbers in the system, if the steady state is obtained.This method to predict the mean fermentation rate and the mean completion of fermentation is different from the graphical method of Deindoerfer and Humphrey, because our method has the function of activity of cell population in the continuous system as its base.L-glutamic acid production by Brevibacterium sp. is investigated as a model case. The results show that the values of mean fermentation rate and mean completion of fermentatin increased with the number of vessels in the system : the piston flow type continuous system may be the most favourable for this kind of fermentation.It is also found that the mean fermentation rate and the mean completion of fermentation behave in oppsite ways with regards to the mean residence time of the system, The possibility to extend our method to "Cell activity-reuse system, " and to apply it to the design of other continuous fermentation processes is also considered.
社団法人日本生物工学会の論文
1964-02-15

連続醗酵によるグルタミン酸生産に関する研究 : (第3報) 細胞活性の分布とその連続醗酵系設計への応用

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