抗生物質生産をともなうアルコール蒸溜廃液処

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Streptomyces strains No. T-82 isolated in our laboratory produces a new antibiotic in the alcohol distillate waste filtrate without the addition of other nuturient substrate.Strain No. T-82 has the morphological and cultural characteristics resembling the S. violaceoniger and S. novaecaesareae. By the culturing of strain No. T-82,the B.O.D. of the waste decreased to about 4,000 ppm (the initial value was 10,000 ppm).The antibiotic was obtained by the cation exchange resin process and treatment of the alminum oxide column-chromatography from the filtrate and mycelium of the broth.It is a basic crystalline compound containing glucosamine amine in its structure, and the result of the elemental analysis indicated the following composition : C 54.3%, H 7.7%, N 6.37%, O 31.61%. It decomposes at 210-215℃.It is active against both Gram-positive and acid-resistance bacteria, and inhibits growth of bacteria at a concentration lower than 5mcg/ml.
公益社団法人日本生物工学会の論文
1963-08-15