New Control Strategies for Continuous Cultures Based upon a Microcomputer-Aided Nutristat

概要

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For continuous biomass production of an ethanol-assimilating yeast, Candida brassicae, four new cultivation methods based upon the nutristat principle with the aid of a microcomputer were proposed. In Method I-1,the feed rate of mineral medium containing ethanol was controlled so as to keep the DO level constant. The ethanol concentration in the culture broth was monitored but not feedback controlled. In Method II-1,the feed rate of ethanol was changed so as to keep its concentration in the culture broth constant and the feed rate of the mineral medium without ethanol was changed so as to keep the DO in the culture broth constant. In Method I-2,the feed rate of mineral medium containing ethanol was varied so as to keep the ethanol concentration in the broth constant while DO was controlled by changing the oxygen partial pressure of inlet gas independently from control of the ethanol concentration in the broth. In Method II-4,the feed rate of mineral medium without ethanol was fixed and the feed rate of ethanol was changed so as to keep the ethanol concentration in the broth constant. DO was automatically controlled in the same way as in Method I-2. In all four methods, a stable steady state was attained, although operational characteristics differed. Biomass productivities based on the same consumption rate of ethanol were almost the same in Methods II-1 and I-2.
社団法人日本生物工学会の論文
1983-06-25