Studies on the Syntheses of Heterocyclic Compounds. DCLXXII. A Synthesis of Coralydine and O-Methylcorytenchirine by Thermolysis of Benzocyclobutene
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概要
- 論文の詳細を見る
A new synthetic method for the tetrahydro-8-methylprotoberberines, coralydine (VIb) and O-methylcorytenchirine (VIa), was described. 3,4-Dimethoxyacetophenone (IX) was converted into 4,5-dimethoxy-2-methylbenzocyclobutene-1-carboxylic acid (XVII) by our method, which was condensed with homoveratrylamine to give N-(3,4-dimethoxy-phenethyl)-4,5-dimethoxy-2-methylbenzocyclobutene-1-carboxamide (XVIII). Thermolysis of the resulting 3,4-dihydroisoquinoline hydrochloride (XXIII), which was obtained by Bischler-Napieralski reaction of XVIII, in bromobenzene followed by sodium borohydride reduction gave VIa and VIb.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
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福本 圭一郎
東北大・薬
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根本 英雄
Pharmaceutical Institute, Tohoku University School of Medicine
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根本 英雄
東北大薬
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大塚 ちさえ
Pharmaceutical Institute, Tohoku University
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亀谷 哲治
Pharmaceutical Institute Medical Faculty University Of Osaka
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福本 圭一郎
Pharmaceutical Institute Tohoku University School Of Medicine
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大塚 ちさえ
Pharmaceutical Institute Tohoku University
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