Studies on Nucleosides and Nucleotides. LXXXVII. Purine Cyclonucleosides. XLII. Synthesis of 2'-Deoxy-2'-fluoroguanosine
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概要
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2'-Deoxy-2'-fluoroguanosine (VII) was synthesized starting from 8,2'-anhydro-8-oxy-9-β-D-arabinofuranosylguanine (8,2'-O-cycloguanosine) (I). Compound I was protected at 2-NH_2 with an isobutyryl group and at 3'- and 5'-OH with tetrahydrofuranyl groups. The protected compound III was derivatized to the arabino nucleoside V and thence converted to VII by treatment with trifluoromethanesulfonyl chloride and tetra-n-butylammonium fluoride. The resulting 2'-deoxy-2'-fluoroguanosine showed a 3'-endo favored conformation.
- 公益社団法人日本薬学会の論文
- 1981-04-25
著者
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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伊村 純子
Faculty of Pharmaceutical Sciences, Osaka University
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伊村 純子
Faculty Of Pharmaceutical Sciences Osaka University
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