Studies of Nucleosides and Nucleotides. XL. Synthesis of 8,5'-O-Cyclonucleoside derived from 8-Oxyguanosine and Its Cleavage by Nucleophilic Reagents

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概要

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• 2', 3'-O-Isopropylidene-8-bromoguanosine was cyclized to 2', 3'-O-isopropylidene-8,5'-anhydro-8-oxyguanosine (II) by the cyclization with sodium hydride in dioxane. 8,5'-Anhydro linkage of the compound II was cleaved by various nucleophiles, such as water, hydrogen sulfide, sodium thiolacetate, sodium acetate, potassium thiocyanate and potassium cyanate in acetic acid to give 5'-substituted 5'-deoxy-8-oxyguanosine. Alkaline hydrolysis of II did not proceed smoothly.

• 公益社団法人日本薬学会の論文
• 1970-06-25

著者

• 宗山 敬

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

• 宗山 敬

  Faculty Of Pharmaceutical Sciences Hokkaido University

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