Studies of Nucleosides and Nucleotides. LXXX. Purine Cyclonucleosides. (38). Synthesis of 6-Substituted Purine 2'-Azido-and 2'-Amino-2'-deoxyribofuranosides
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概要
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Starting from 2'-azido-2'-deoxyadenosine (1), sugar-acetylated 6-chloro compound (5) was synthesized by successive deamination, acetylation and chlorination. Using the compound 5 as intermediate 6-monomethylamino-, dimethylamino-, mercapto- and methylthio 2'-azido nucleosides (6,8,11 and 12) were obtained. Palladium-catalyzed hydrogenation of compound 6 and 8 afforded 2'-amino nucleosides (7 and 9) respectively.
- 公益社団法人日本薬学会の論文
- 1978-03-25
著者
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高塚 陽子
Faculty of Pharmaceutical Sciences, Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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高塚 陽子
Faculty Of Pharmaceutical Sciences Osaka University
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