<基礎的研究発生病理>腎皮質抽出物の血管障害作用とACE阻害剤の影響について

概要

論文の詳細を見る
The renal cortex of old M-SHRSP and/or SHRSP contains a larger amount of vascular injury substance than that of WKY. On the other hand, we have clarified that angionecrosis in various organs disappeared following treatment with angiotensin converting enzyme inhibitors (ACEI). This study was conducted to prove whether the vascular injury effect of renal cortical extracts changed following ACEI treatment. 11-week-old male M-SHRSP had been treated with ACEI for 5 weeks, and then the renal cortical extract (fraction 4) of the treated M-SHRSP, untreated M-SHRSP and SHR B2 were obtained according to a modification of the method of Nakamura et al.. Then each fraction was injected intraperitoneally to bilaterally nephrectomized WKY. Compared to various fractions, the renal cortex of M-SHRSP treated with ACEI contained a smaller amount of the vascular injury substance than the untreated M-SHRSP and SHR B2.
近畿大学の論文
1993-12-30