<基礎的研究発生病理>SHRとWKYの心筋におけるSOD活性とフリーラジカル障害の比較

概要

論文の詳細を見る
To elucidate the myocardial vulnerability of the hypertrophied myocardium in the SHR, the superoxide dismutase (SOD) activity was examined using the mitochondrial and cytosol fraction of 4- and 24-week-old SHR and WKY. Furthermore, superoxide anion production was compared histochemically by the Nitroblue tetrazolium (NBT) perfusion method in 16-week-old SHR and WKY after doxorubicin administration. At 4 weeks of age, the Mn-SOD activity in the mitochondrial fraction was higher in the myocardium in the SHR than in the WKY, whereas no difference was found at 24 weeks of age. CuZn-SOD in the cytosol fraction was significantly lower in the myocardium in the SHR than in the WKY both at 4 and 24 weeks of age. On the other hand, holmazan formation which was generated from NBT by the superoxide anion was more intense in the myocardium in the SHR than in the WKY after doxorubicin administration. These findings indicate that the decreased defense system for free radical injury may be an important factor for myocardial vulnerability in the SHR hypertrophied heart.
近畿大学の論文
1993-12-30