<基礎的研究発生病理>SHR肥大心における細胞障害易発症性と脂質過酸化

概要

論文の詳細を見る
To elucidate the pathogenesis of myocardial vulnerability in hypertrophied SHR, myocardium biochemical changes in blood and myocardium were compared with those in WKY on the 1st and 4th day. Both treated SHR and WKY hearts were heavier than those of the respective control. On the 1st day, the plasma GOT level and on the 4th day, LDH and CPK levels were higher in treated SHR than in the saline group, but not in WKY, showing severe myocardial damage in the SHR heart. Na^+/K^+-ATPase activity was lower in the treated SHR on the 1st and 4th day than in the saline group. Thiobarbituric acid reactant substance was significantly higher in the treated SHR on the 1st and 4th day than that in the saline group, but not in the case of WKY. These results support the previous morphological findings and suggest that membrane lipid peroxidation is a causative factor for myocardial vulnerability in hypertrophied SHR myocardium.
近畿大学の論文
1990-12-30