動脈硬化症における細胞外マトリックスとそれに関連する成長因子の発現(<特集>動脈硬化と細胞外マトリックス)

概要

論文の詳細を見る
The extracellular matrix (ECM) is important constituent of vascular wall and is closely related in the pathogenesis of atherosclerosis. Vascular ECM is composed of different components, such as collagen, elastin and proteoglycans. Immunohistochemical examination of such elements was carried out in human aortic atherosclerosis. Although the expression and distribution of these constituents differ among the preparations, this may be due to different arterial segments examined and the severity of the lesions. The results showed that very drastic changes in ECM could occur during atherogenesis and greatly contribute to the pathogenesis of atherosclerosis. In this review, the pathophysiological implications of ECM are discussed with special references to the phenotypic change of SMC and lipid deposition in the thickened intima.
日本結合組織学会の論文
2002-12-25