<基礎的研究発生病理>M-SHRSPにおけるcorticosterone, DOCの加齢による変動について

概要

論文の詳細を見る
M-SHRSP blood pressure rose above 220 mmHg at 8 weeks of age. At the same time, plasma TSH and plasma DOC in M-SHRSP began to exceed those in WKY. However the M-SHRSP plasma corticosterone level began to drop. On the other hand, intraperitoneal injection of corticosterone lowered the plasma TSH level in 8-week-old M-SHRSP, to below the controls level. However, the blood pressure in these M-SHRSP was as high as in the control M-SHRSP. These findings indicate that corticosterone is not directly related to the development of hypertension. Therefore, TSH and DOC may be more closely related to the development of hypertension in its earlier stages than are either aldosterone or renin.
近畿大学の論文
1990-12-30