SHRSPの視神経乳頭部の網膜血管, 脳血管, 腎血管におけるHistofluorescence Microscopyによる観察(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
Permeability of retinal, cerebral and renal vessels in Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) from 6-months to 9-months of age was histologically studied by using fluorescein microscopy. In the retinal and cerebral vessels of WKY, fluorescein was detectable only in the lumen of the retinal and cerebral vessels. In the renal vessels of WKY, fluorescein dye was observed both in the lumen of the vessels and around the vessels. When the retinal, cerebral and renal tissues of SHRSP were examined by the same methods, an increase in fluorescein permeability was observed. Fluorescein dye leaked most severely out of the retinal vessels near the optic disc. In the optic nerve, fluorescein dye was also found to leak out of the choroidal vessels. In the cerebral tissues of some SHRSP, blood flow was blocked by the increased intracranial pressure and fluorescein was detectable neither in the lumen nor the stroma of the cerebral tissue. In the renal capillaries, many occlusive lesions were observed in SHRSP. Thus histofluorescence microscopy may contribute to the understanding of histological changes in the fluorescein angiography.
近畿大学の論文
1984-12-25