<基礎的研究発生病理>M-SHRSPにおける脳血管病変の研究に関するMRIの有用性について

概要

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Magnetic resonance imaging (MRI) is useful for the detection of various lesions. In this study, using M-SHRSP, a useful animal model for studying human malignant hypertension, MRI and histopathological analysis was conducted to secure basic data for the onset and development of cerebrovasular lesions. In the T2 weighted images, edema and/or infarct was shown as an increased intensity area, and hemorrhage was shown as a decreased intensity area. In the T1 weighted images, these lesions were usually shown as decreased intensity area. Edema and infarct were clearer in the coronal T2 weighted images than in the coronal T1 weighted images. However, after Magnevist injection, T1 weighted images clearly showed a blood-brain barrier injured area. Both MRI and histopathological findings were scored. Comparison of the above score value shows MRI and histopathological findings to correlate excellently. Continuous MRI observation of M-SHRSP from a young stage of life showed the process of development of cerebrovascular lesions. As a result, MRI usage seems very useful for detailed characterization of cerebrovascular lesions for M-SHRSP in vivo.
近畿大学の論文
1992-12-30