<基礎的研究発生病理>M-SHRSPにhydralazine hydrochlorideを投与したときの血漿レニンおよびアルドステロンの変動について

概要

論文の詳細を見る
Hydralazine hydrochloride was administered for seven days to 10-week-old male M-SHRSP and changes in blood pressures, plasma renin concentrations (PRC) and plasma aldosterone concentration (PAC) were monitored for a period of 7 days. High blood pressures, (267±8.0mmHg) prior to administration of hydralazine hydrochloride, showed a statistically significant averate fall of about 30mmHg. The PRC, which was high (48.5±9.3ng/h/ml) prior to this treatment, fell gradually to 29.2±6.8ng/h/ml, and the PAC, which was also high (4,423±147.2pg/ml) prior to this treatment, fell significantly to 166±66.0pg/ml on the 7th day. The administration of hydralazine hydrochloride had no effect on the thickness of the zona glomerulosa of the adrenal cortex.
近畿大学の論文
1988-12-30