M-SHRSPおよびその諸種交雑子孫の血圧, 脳病変その他について第2報 M-SHRSPとWKYの交雑子孫について(I 発生病理)(A 基礎的研究)

概要

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Successive selective breeding of M-SHRSP has been continued through the 16th generation. Findings to date show that the blood pressures of M-SHRSP increase more precociously than do those of SHRSP, and that the PRA of M-SHRSP is extremely high at an early stage of life, being about 6-7 times that of WKY at 12-15 weeks of age. Their average life span is about half that of SHRSP, and the incidence of stroke lesions in them is over 95%. All this indicates that M-SHRSP is an animal model with severest hypertension. Various crosses and backcrosses using M-SHRSP, WKY, and their hybrids have resulted in the development of colonies with blood pressures ranging from 135 to 250 mmHg. And, the severe hypertensive factor in M-SHRSP diminishes as a result of 3 or 5 backcrosses and stroke lesions disappear as a result of a single cross with WKY.
近畿大学の論文
1983-12-30