<予防および治療>M-SHRSPに及ぼす二, 三の降圧剤, 食餌の影響 : 治療開始時期の違いによる予防, 治療効果について

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M-SHRSP is an animal model with severe hypertension at an early stage of life as well as an extremely short life span. Using M-SHRSP, the therapeutic effects of hydralazine hydrochloride, captopril, SQ 29,852 and a 33% fish meal diet started at different stages of life were examined from the standpoint of the development of stroke lesions and angionecrosis. The rats were divided into two groups : (A) treatment starting from 5 weeks of age (early development of hypertension), and (B) treatment starting from 10 to 11 weeks of age (established hypertension). All treatments started from 5 weeks of age, suppressed any further increases in blood pressure ; the order of effectiveness being : SQ 29,852>captopril>hydralazine>fish meal. Furthermore, life span for all of the treated groups were over two and a half times longer than those of the untreated control group. At 10 weeks after the start of treatment for groups given either SQ 29,852,captopril or hydralazine starting from 10 to 11 weeks of age, there were temporary decreases in blood pressure from 20 to 30 mmHg. Also, life span was markedly longer for these groups as it was for those groups starting at 5 weeks of age. However, for the fish meal group, suppression of increase in blood pressure was slight and life span prolongation limited. The incidence rates for stroke lesions and angionecrosis for those grpups given hydralazine or fish meal were as high as for the control group, regardless of when treatment was initiated. However, regardless of age at the start of treatment, no stroke lesions developed and the incidence rates for angionecrosis of the brain, heart and kidneys were very low even though blood pressure was over 220 mmHg. These results suggest that the two ACE inhibitors used in this study are effective in the prevention and repair of angionecrosis which, in turn, results in prevention of stroke lesions and in a lengthening of life span.
近畿大学の論文
1990-12-30

<予防および治療>M-SHRSPに及ぼす二, 三の降圧剤, 食餌の影響 : 治療開始時期の違いによる予防, 治療効果について

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