<予防および治療>M-SHRSPの重症高血圧症におよぼすカプトプリル, 塩酸ヒドララジンおよび魚粉食の影響

概要

論文の詳細を見る
Using M-SHRSP a useful animal model for studying human malignant hypertension, we made studies on the prevention of and therapy for malignant hypertension. Drugs selected for use were captopril and hydralazine hydrochloride. The rats were also fed a 33% fish meal diet. When given separately, these drugs and a fish meal diet were shown to be anti-hypertensive. However, the fish meal diet combined with hydralazine was more effective than the drugs or fish meal diet given separately, while the effect of hydralazine combined with captopril was even greater than that of the combined fish meal diet and hydralazine treatment. In particular, using the fish meal diet and hydralazine combined with captopril lowered blood pressures to a near normal level. Some rats were resistant to treatment. In M-SHRSP, treatment with captopril alone, stuppressed the occurrence of hypertensive vascular lesions (especially angionecrosis) in the brain, heart and kidneys and greatly prolonged life span, even though these rats continued to have a significantly high blood pressure. These results suggested that in malignant hypertensiota, factors other than high blood pressure itself, but which interact with its effects play a role in the occurrence of such hypertensive vascular lesions as angionecrosis.
近畿大学の論文
1989-12-30