<原著>原発性肺高血圧症2例における血管拡張剤の治療効果

概要

論文の詳細を見る
Primary pulmonary hypertension is a disease characterized by a progressive downhill course without effective therapeutic measures and unknown pathogenesis. It has been reported that various vasodilators would be effective in reducing pulmonary vascular resistance. In this paper, the effects of vasodilators in two patients with primary pulmonary hypertension have been reported. In the first case, the cardiac output rose from 2.34 to 2.73 l/min following intravenous administration of 2 mg of verapamil accompanied by a decrease of mean pulmonary artery pressure from 57 to 52 mmHg. The effects of isoproterenol, reserpine and hydralazine were found unfavourable. In the second case, the cardiac output rose from 2.18 to 3.29 l/min following sublingual administration of nifedipine 20 mg accompanied by a decrease of right ventricular systolic pressure from 140 to 124 mmHg. Isoproterenol, hydralazine and diazoxide showed no effect in reducing pulmonary vascular resistance. Two patients died on the 108th and 158th hospital day in spite of many attempts to reduce pulmonary hypertension. It was concluded that verapamil and nifedipine were effective for short use and that the latter was also useful for a relatively long period, because of the temporary reduction of pulmonary vascular resistance, increase of cardiac output and relief of dyspnea.
近畿大学の論文
1983-06-25