SHRSPにおけるイソプロテレノール誘発心筋障害の形態学的・心電図学的研究(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
As a basic experiment on the hypertensive or ischemic heart diseases, myocardial changes in SHRSP after injection of isoproterenol were examined morphologically and electrocardiogramically, in comparison with those in normotensive WKY. The subcutaneous injection of isoproterenol easily induced severe myocardial changes in SHRSP and this effect was more predominant in mature SHRSP but not so remarkable in young SHRSP and in WKY. Short-term antihypertensive treatment did not influence the myocardial changes in mature SHRSP, but the long-term treatment seemed to be slightly effective to prevent the myocardial changes. These results suggest that hypertension and/or hypertrophy of the heart must be the most important risk factors in myocardial changes.
近畿大学の論文
1983-12-30