<基礎的研究発生病理>副腎髄質核出時におけるM-SHRSPの延髄カテコールアミンの変動について

概要

論文の詳細を見る
Catecholamines are synthesized in the brain, sympathetic nerve and adrenal medulla, and catecholamine neurons in the medulla participate in the central regulation of blood pressure. In this study, we axamined the catecholamines in the medulla on the condition of bilaterally enucleating adrenal medulla to clarify the participation for the medulla in the severe hypertension. M-SHRSP showed blood pressure of about 170 mmHg at 6 weeks and around 270 mmHg at 10 weeks. WKY is a normotensive rat. There was no change in blood pressure by enucleation in either rat. The norepinephrine store in the medulla of M-SHRSP was lower than that of WKY at any age. Norepinephrine store in the medulla of SHR has been report to be lower than that of WKY at only the prehypertensive stage. Since NTS of the medulla is a depressor region, decreased norepinephrine levels in this region would be expected to increase sympathetic nervous system excitation during the development and maintenance of severe hypertension.
近畿大学の論文
1991-12-30