SHRSPの網膜および視神経の血管基底膜の検討

概要

論文の詳細を見る
In stroke-prone spontaneously hypertensive rats (SHRSP), disc swelling frequently occurs after cerebral strokes. To investigative the distribution of blood vessels in the retina and optic nerve of SHRSP, the authors stained the basement membrane of microvessels with the antibody against laminin or type IV collagen by using indirect immunofluorescent microscopy. Specific fluorescence for laminin or collagen type IV was observed at the blood vessels in the retina, choroid or optic nerve of WKY. In the optic nerve of SHRSP, hypertensive angionecrotic changes were observed and the basement membrane proteins were observed not only around the microvessels but also outside the vessels and these fluorescent dyes were observed in the optic nerve tissue. The prolonged hypertensive papilledema seems to induce the organic changes of the optic nerve of SHRSP.
近畿大学の論文
1987-12-30