<基礎的研究発生病理>SHRにおける高血圧とreninの関係についての2,3の研究

概要

論文の詳細を見る
In spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP) and malignant SHRSP (M-SHRSP), changes in plasma renin concentration (PRC) and renal renin concentration (RRC) due to the development of hypertension were studied and discussed in relation to hypertension. PRC values for SHR C and SHR B_2 did not exceed the normal values found for the control WKY (Wistar-Kyoto rats). There were extraordinary increases in PRC for both SHRSP and M-SHRSP ; however PRC values remained normal even for these strains as long as their blood pressures were below 210 mmHg. PRC levels began to increase sharply when blood pressure exceeded 210 mmHg and the subsequent increases in blood pressure and PRC level were positively correlated. There was also a positive correlation between PRC and RRC in M-SHRSP. These results suggest that the increase in PRC found in SHRSP and M-SHRSP with high blood pressure levels is a result of this extraordinary rise in blood pressure (above 210 mmHg) and that the increased PRC, in turn, further aggravates the hypertension.
近畿大学の論文
1986-12-30