高血圧性血管病変の発生病理 : SHRSPの腸間膜動脈における高血圧性血管病変(I 発生病理)(A 基礎的研究)

概要

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Morphological studies using histological, histometrical, tetralin clearing and electron microscopical methods were conducted in order to investigate the pathogenesis of periarteritis nodosa (PN)-like lesions in the mesenteric arteries of SHRSP.In SHRSP, the mesenteric arteries were dilated, especially in the terminal arcades. Most of PN-like lesions were located in the convexities of the terminal arcades. The incidence of these lesions was 22% in males and 31% in females. Electron microscopically, the endothelial cell junctions were remarkably loosened in these regions. Histologically and scanning electron microscopically, intra-arterial cushions were found at the bifurcation of the vasa rectae from the terminal arcade. And in SHRSP, the hematocrit ratio of the vasa rectae was significantly higher than that of the terminal arcade. These findings seem to result from the cell-skimming function of the above-mentioned intra-arterial cushion, which causes a hypoxic state in the terminal arcade. Such a hypoxic state induced by intra-arterial cushions and the blood stagnation due to arcade formation in addition to hypertension seem to accelerate the incidence of PN-like lesions in the mesenteric arteries of SHRSP.
近畿大学の論文
1984-12-25