<基礎的研究発生病理>SHRの肥大心における細胞内小器官の病態

概要

論文の詳細を見る
In order to clarify the pathogenesis of hypertrophied heart myocardial injuries, a number of enzymes were examined in both prehypertensive and hypertensive SHR, and compared with those in WKY. Results showed that at 6 weeks of age, ICDH activity in the mitochondrial fraction was higher in SHR than in WKY, but that at 16 weeks it was lower. Similar changes were observed in Na^+/K^+-ATPase activity in the microsomal fraction, one of the plasma membrane marker enzymes. However, 5'-nucleotidase activity, another plasma membrane marker enzyme, was slightly higher at 16 weeks of age in SHR than it was in WKY. It was also found that NAG and AcP in the lysosomal fraction were higher in SHR than they were in WKY at 6 weeks of age, but that at 16 weeks of age, while NAG was still higher, AcP was lower in SHR than it was in WKY. These results indicate that, compared to those of lysosomes, mitochondria and plasma membrane alterations are more important as causative factors in the initiation of SHR hypertrophied heart myocardial changes.
近畿大学の論文
1988-12-30