<原著>本態性高血圧症およびSHRSPにおける病期進展と平均血小板容積, 血小板数の変動

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The purpose of the present study is to clarify the clinical significance of platelet changes in various stages of essential hypertensive (EHT) and stroke-prone spontaneously hypertensive rats (SHRSP). Mean platelet volume (MPV) and platelet count (PLT) were measured by a Coulter Counter Model S-Plus and blood pressure was measured by Riva-Rocci type sphygmomanometer in humans and by the tail pulse pick-up method in rats. The subjects consisted of 154 normal subjects (54±3 y.o.), 43 EHT in stage I (59±11 y.o.), 22 EHT in stage II (58±12 y.o.), 32 EHT in stage III (60±15 y.o.), 20 Wistar-Kyoto rats (WKY) and 23 SHRSP. In EHT, systolic blood pressure was significantly high in stage II and stage III as compared to stage I and there were no significant diastolic blood pressure changes among stage I, stage II and stage III. MPV had a tendency to increase and PLT to decrease with the advance of the stage of EHT. Systolic blood pressure was significantly high in adult SHRSP as compared to young SHRSP, young WKY and adult WKY. MPV and PLT exhibited significant negative correlation in SHRSP and WKY. MPV and systolic plood pressure exhibited significant positive correlation in SHRSP and WKY. The platelet changes in SHRSP were similar to those of EHT. We reported previously that a decrease in platelet taurine might play a role in increasing MPV in EHT. The results of the present study indicate that in addition to the membrane abnormality due to the decrease in platelet taurine, hypertensive vascular changes may play an important role in inducing the platelet changes in EHT.
近畿大学の論文
1985-03-25

<原著>本態性高血圧症およびSHRSPにおける病期進展と平均血小板容積, 血小板数の変動

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