<予防および治療>M-SHRSPの高血圧性血管病変に対する各種降圧剤の影響について : とくに投与量と降圧効果, 脳病変および脳, 腎の小動脈にみられる血管壊死治癒効果との関係について

概要

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After 11 weeks of age, all male M-SHRSP have obvious cerebrovascular lesions and angionecrosis of the arterioles in the brain and/or the kidney. Eleven-week-old male M-SHRSP were given in their diet SQ 29,852 and captopril as angiotensin converting enzyme inhibitors and manidipine hydrochloride and AE0047 as calcium antagonists. They were also given hydralazine hydrochloride as a vascular smooth muscle relaxant in their drinking water in various doses to each treatment group. Histopathologically, no cerebrovascular lesion and angionecrosis of the brain and renal arterioles were detected in other treatments, except in the hydralazine treatment. Furthermore, the treatments were more effective when the doses were increased.On administration of 10 mg/kg/day SQ 29,852 or manidipine, disappearance of arteriolar angionecrosis was similar to other treatments except for the hydralazine treatment in spite of the mild anti-hypertensive effect from 280 mmHg to 260 mmHg. The administration of anti-hypertensive drugs, which have quite different effects on the vasculature, indicated the following ; l) Disappearance of angionecrosis (healing effects) does not always depend on anti-hypertensive effect alone. 2) The disappearance of angionecrosis is related to some other factor besides lowering of the blood pressure and the function of these drugs.
近畿大学の論文
1992-12-30