SHRSPの高血圧因子について(予報)(A 基礎的研究)(I 発生病理)

概要

論文の詳細を見る
Crosses were made between stroke-prone SHR (SHRSP) and Wistar-Kyoto (WKY) rats. The hybrids (F_1) were inter- and backcrossed to the parental strain, as well as crosses continued for several generations. The offsprings were investigated for blood pressures, the incidences of stroke and so on. The following results were obtained : (1) Development of hypertension in SHRSP is not in accordance with the simple Mendelian law. (2) The F_1 hybrid did not demonstrate stroke lesions. (3) The F_1 and F_2-F_4 hybrids (derived from WKY and F_1,WKY and F_2,and WKY and F_3) showed gradually lower blood pressure until finally it became close to that of WKY. (4) It seems that we can obtain various strains which show separately, varied blood pressure levels, ranging from that of SHRSP to that of WKY.
近畿大学の論文
1980-09-25