<基礎的研究発生病理>重症の高血圧性血管病変を有するラットの腎皮質抽出液による血管障害について

概要

論文の詳細を見る
We have proposed the hypothesis that factors in malignant hypertension other than high blood pressure itself may play a role in the occurrence of such hypertensive vascular lesions as angionecrosis. In this study, we tried to clarify whether there were any substances in M-SHRSP and/or SHRSP renal cortex which induced vascular lesions without high blood pressure. The renal cortex of M-SHRSP, SHRSP and WKY were fractionated to F1-F5 according to a modification of the method of Nakamura et al.. To examine the vascular injury effect, each fraction was injected intraperitoneally to nephrectomized WKY. Compared to various fractions, F4 (containing lysosomal contents) extracted from the old M-SHRSP and/or SHRSP renal cortex showed the greatest vascular injury effect (inducing angionecrosis) especially in the pancreas and mesenterium. The renal cortex of M-SHRSP and SHRSP with severe hypertensive vascular lesions contained a larger amount of vascular injury substance than WKY.
近畿大学の論文
1993-12-30