SHRSPの動脈壁弾性線維の電顕的および顕微分光学的研究(A 基礎的研究)(I 発生病理)

概要

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Elastic fibers in the mesenteric arteries of SHRSP, compared with those of WKY, were examined electronmicroscopically and staining characteristics were examined with a microspectro-photometer. Destruction of elastic fibers and degenerative changes were observed in TEM pictures of the mesenteric arteries of 200-day-old SHRSP. A migration of medial smooth muscle cells was observed and collagen fibers were found to be abundant in the media ; thus indicating that the normal mesenteric arterial structure was not maintained. The staining characteristics of elastic fibers after Weigert's method were examined both in SHRSP and WKY at 40 and at 100 days of age. The colors differed among preparations, even for the 40-day-old rats. The elastic fibers in WKY were stained a more reddish and brighter hue in comparison with those in SHRSP. These results indicate a possibility that the elastic fibers of the mesenteric arteries of SHRSP, in comparison with WKY, are altered in a very early stage in life.
近畿大学の論文
1980-09-25