Newly Synthesized Oleylgingerol and Oleylshogaol Activate TRPV1 Ion Channels

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概要

• 論文の詳細を見る

• The oleyl moiety in vanilloids is important in activating vanilloid receptor 1 (TRPV1), but there was no ingredient of ginger containing the oleyl moiety in the natural form. We synthesized oleylgingerol and oleylshogaol and then evaluated their potential to activate a rat TRPV1 channel. Oleylgingerol is a stronger TRPV1 agonist than natural gingerols, but oleylshogaol is a weaker agonist than natural shogaols. The difference in structure between oleylgingerol and oleylshogaol is only the hydroxy group at carbon-5. This hydroxy group might have an important role in activating a TRPV1 channel.

• 社団法人 日本農芸化学会の論文

著者

• Iwasaki Yusaku

  School of Food and Nutritional Sciences, University of Shizuoka

• WATANABE Tatsuo

  School of Food and Nutritional Sciences, University of Shizuoka

• KOBATA Kenji

  School of Food and Nutritional Sciences, University of Shizuoka

• Kobata Kenji

  Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka

• Kobata Kenji

  School Of Food And Nutritional Sciences University Of Shizuoka

• Iwasaki Yusaku

  Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka

• Watanabe Tatsuo

  School Of Food And Nutritional Sciences Univ. Of Shizuoka

• MORITA Akihito

  School of Food and Nutritional Sciences, University of Shizuoka

• YOKOGOSHI Hidehiko

  School of Food and Nutritional Sciences and COE Program in the 21st Century, University of Shizuoka

• Yokogoshi Hidehiko

  School Of Food And Nutritional Sciences And Coe Program In The 21st Century The University Of Shizuo

• Kobata Kenji

  Department Of Nutrition And Food Science Ochanomizu University

• Kobata Kenji

  School Of Food And Nutritional Sciences And Coe Program In The 21st Century University Of Shizuoka

• Iwasaki Yusaku

  School Of Food And Nutritional Sciences And Coe Program In The 21st Century University Of Shizuoka

• Morita Akihito

  School Of Food And Nutritional Sciences And Coe Program In The 21st Century University Of Shizuoka

• Watanabe Tatsuo

  School Of Food And Nutritional Sciences And Coe Program In The 21st Century University Of Shizuoka

• WATANABE Tatsuo

  School of Food and Nutritional Sciences and COE Program in the 21st Century, University of Shizuoka

• KOBATA Kenji

  School of Food and Nutritional Sciences and COE Program in the 21st Century, University of Shizuoka

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