TRPA1 Agonists-Allyl Isothiocyanate and Cinnamaldehyde-Induce Adrenaline Secretion
スポンサーリンク
概要
- 論文の詳細を見る
Thermosensitive transient receptor potential (TRP) channels, especially TRPV1 and TRPA1, are activated by the pungent compounds present in spices. TRPV1 activation by the intake of capsaicin, the irritant in hot pepper, induces adrenaline secretion and increases energy consumption. TRPV1 is mainly expressed in the sensory neurons and coexpressed with TRPA1 at a high frequency. However, the mechanism underlying adrenaline secretion by TRPA1 agonists such as allyl isothiocyanate (AITC) and cinnamaldehyde (CNA), the pungent ingredients in mustard and cinnamon, is not known. We examined whether AITC and CNA could induce adrenaline secretion in anesthetized rats. An intravenous injection of AITC or CNA (10 mg/kg) increased adrenaline secretion. These responses disappeared completely in capsaicin-treated rats with an impaired sensory nerve function. Moreover, pretreatment with cholinergic blockers (hexamethonium and atropine) attenuated the AITC- or CNA-induced adrenaline secretion. These results suggest that TRPA1 agonists activate the sensory nerves and induce adrenaline secretion via the central nervous system.
- 社団法人 日本農芸化学会の論文
- 2008-10-23
著者
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Kobata Kenji
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
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Iwasaki Yusaku
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Watanabe Tatsuo
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences University Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences Univ. Of Shizuoka
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences And Coe Program In The 21st Century Univ.
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Tanabe Manabu
Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shiz
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Kobata Kenji
Department Of Nutrition And Food Science Ochanomizu University
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Tanabe Manabu
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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WATANABE Tatsuo
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka
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