Capsaicinol : Synthesis by Allylic Oxidation and Its Effect on TRPV1-Expressing Cells and Adrenaline Secretion in Rats
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概要
- 論文の詳細を見る
Capsaicinol is an ingredient of hot red pepper. In this study, we developed a novel method for capsaicinol synthesis and examined capsaicinol’s physiological effects on capsaicin receptor (TRPV1)-related actions. Allylic oxidation of capsaicin by palladium acetate (Pd(OAc)2) resulted in the formation of (±)-capsaicinol acetate at a 7.2% yield in a single step. The effectiveness of (±)-capsaicinol in TRPV1 activation (EC50=1.1 μM) was found to be weaker than that of capsaicin (EC50=0.017 μM), whereas the efficacy of (±)-capsaicinol reached 75% of that of capsaicin. Intravenous administration of (±)-capsaicinol in anesthetized rats dose-dependently enhanced adrenaline secretion from the adrenal gland. The response to a 5 mg/kg-dose of (±)-capsaicinol was comparable to that of a 0.05 mg/kg-dose of capsaicin. The relative pungency of capsaicinol to capsaicin was coincident with the relative effectiveness in inducing these TRPV1-related actions.
- 社団法人 日本農芸化学会の論文
- 2006-08-23
著者
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Kobata Kenji
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
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Kobata Kenji
School Of Food And Nutritional Sciences University Of Shizuoka
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Iwasaki Yusaku
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Watanabe Tatsuo
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences University Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences Univ. Of Shizuoka
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences And Coe Program In The 21st Century Univ.
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IWASAWA Takahito
Graduate School of Nutritional and Environmental Sciences and COE program in the 21st century, Unive
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MORITA Akihito
Graduate School of Nutritional and Environmental Sciences and COE program in the 21st century, Unive
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SUZUKI Yuichi
Graduate School of Nutritional and Environmental Sciences and COE program in the 21st century, Unive
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KIKUZAKI Hiroe
Graduate School of Human Life Science, Osaka City University
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NAKATANI Nobuji
Graduate School of Human Life Science, Osaka City University
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Kikuzaki Hiroe
Dep. Of Food And Human Health Sciences Graduate School Of Human Life Sci. Osaka City Univ.
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Nakatani Nobuji
Graduate School Of Human Life Science Osaka City University
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Kobata Kenji
Department Of Nutrition And Food Science Ochanomizu University
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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Iwasawa Takahito
Graduate School Of Nutritional And Environmental Sciences And Coe Program In The 21st Century Univer
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Suzuki Yuichi
Graduate School Of Human Health Sciences Tokyo Metropolitan University
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Suzuki Yuichi
Graduate School Of Nutritional And Environmental Sciences And Coe Program In The 21st Century Univer
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WATANABE Tatsuo
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka
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SUZUKI Yuichi
Graduate School of Engineering, Kyushu University
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