TRPV1 Agonist Monoacyglycerol Increases UCP1 Content in Brown Adipose Tissue and Suppresses Accumulation of Visceral Fat in Mice Fed a High-Fat and High-Sucrose Diet
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概要
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The administration of such a transient receptor potential vanilloid 1 (TRPV1) agonist as capsaicin, which is a pungent ingredient of red pepper, promotes energy metabolism and suppresses visceral fat accumulation. We have recently identified monoacylglycerols (MGs) having an unsaturated long-chain fatty acid as the novel TRPV1 agonist in foods. We investigated in this present study the effects of dietary MGs on uncoupling protein 1 (UCP1) expression in interscapular brown adipose tissue (IBAT) and on fat accumulation in mice fed with a high-fat, high-sucrose diet. The MG30 diet that substituted 30% of all lipids for MGs (a mixture of 1-oleoylglycerol, 1-linoleoylglycerol and 1-linolenoylglycerol) significantly increased the UCP1 content of IBAT and decreased the weight of epididymal white adipose tissue, and the serum glucose, total cholesterol and free fatty acid levels. The diet containing only 1-oleoylglycerol as MG also increased UCP1 expression in IBAT. MGs that activated TRPV1 also therefore induced the expression of UCP 1 and prevented visceral fat accumulation as well as capsaicin.
- 2011-05-23
著者
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Chiba Hiroshige
Faculty Of Pharmaceutical Sciences Josai University
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Kobata Kenji
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
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Iwasaki Yusaku
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences University Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences Univ. Of Shizuoka
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences And Coe Program In The 21st Century Univ.
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Narukawa Masataka
Graduate School Of Agriculture Kyoto University
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Kobata Kenji
Department Of Nutrition And Food Science Ochanomizu University
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Narukawa Masataka
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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TAMURA Yasuko
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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INAYOSHI Kimiko
School of Food and Nutritional Sciences, University of Shizuoka
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MURAKI Etsuko
Faculty of Pharmaceutical Sciences, Josai University
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TSUNODA Nobuyo
Faculty of Pharmaceutical Sciences, Josai University
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Tamura Yasuko
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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Tsunoda Nobuyo
Faculty Of Pharmaceutical Sciences Josai University
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Muraki Etsuko
Faculty Of Pharmaceutical Sciences Josai University
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Inayoshi Kimiko
School Of Food And Nutritional Sciences University Of Shizuoka
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NARUKAWA Masataka
Graduate School of Agricultural and Life Sciences, The University of Tokyo
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WATANABE Tatsuo
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka
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