Capsaicin-, Resiniferatoxin-, and Olvanil-induced Adrenaline Secretions in Rats via the Vanilloid Receptor(Food & Nutrition Science)
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概要
- 論文の詳細を見る
The effects of capsaicin analogs on adrenaline secretion were investigated in rats. Capsaicin (20-100μg/kg, iv) caused biphasic adrenaline secretion. Capsazepine (20 mg/kg, iv), a specific competitive antagonist of the vanilloid (capsaicin) receptor, strongly inhibited both phases of adrenaline secretion by capsaicin (50μg/kg). Next, the effects of two capsaicin analogs on the adrenal catecholamine secretion were examined. Resiniferatoxin (20-200 ng/kg, iv), a naturally occurring phorbolester-like compound, provoked slow onset adrenaline secretion in a dose-dependent manner. Olvanil (2.46-246μg/kg, iv), a synthesized non pungent capsaicin analog, also stimulated delayed catecholamine secretion dose-dependently. Capsazepine (20 mg/kg, iv) pretreatment prevented the resiniferatoxin (50 ng/kg)-and olvanil (24.6μg/kg)-induced catecholamine secretion. These results suggest that some vanilloids (capsaicin, resiniferatoxin, olvanil) excite adrenaline secretion and such excitation is via the vanilloid receptor.
- 社団法人日本農芸化学会の論文
- 2001-11-23
著者
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WATANABE Tatsuo
School of Food and Nutritional Sciences, University of Shizuoka
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KOBATA Kenji
School of Food and Nutritional Sciences, University of Shizuoka
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Kobata Kenji
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
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Kobata Kenji
School Of Food And Nutritional Sciences University Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences University Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences Univ. Of Shizuoka
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SAKURADA Nobuo
School of Food and Nutritional Sciences, University of Shizuoka
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Sakurada Nobuo
School Of Food And Nutritional Sciences University Of Shizuoka
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Kobata Kenji
Department Of Nutrition And Food Science Ochanomizu University
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Kobata Kenji
School Of Food And Nutritional Sciences And Coe Program In The 21st Century University Of Shizuoka
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Watanabe Tatsuo
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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Watanabe Tatsuo
School Of Food And Nutritional Sciences And Coe Program In The 21st Century University Of Shizuoka
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