TRPA1 Agonists—Allyl Isothiocyanate and Cinnamaldehyde—Induce Adrenaline Secretion

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概要

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• Thermosensitive transient receptor potential (TRP) channels, especially TRPV1 and TRPA1, are activated by the pungent compounds present in spices. TRPV1 activation by the intake of capsaicin, the irritant in hot pepper, induces adrenaline secretion and increases energy consumption. TRPV1 is mainly expressed in the sensory neurons and coexpressed with TRPA1 at a high frequency. However, the mechanism underlying adrenaline secretion by TRPA1 agonists such as allyl isothiocyanate (AITC) and cinnamaldehyde (CNA), the pungent ingredients in mustard and cinnamon, is not known. We examined whether AITC and CNA could induce adrenaline secretion in anesthetized rats. An intravenous injection of AITC or CNA (10 mg/kg) increased adrenaline secretion. These responses disappeared completely in capsaicin-treated rats with an impaired sensory nerve function. Moreover, pretreatment with cholinergic blockers (hexamethonium and atropine) attenuated the AITC- or CNA-induced adrenaline secretion. These results suggest that TRPA1 agonists activate the sensory nerves and induce adrenaline secretion via the central nervous system.

• 社団法人 日本農芸化学会の論文

著者

• Kobata Kenji

  Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka

• Kobata Kenji

  School Of Food And Nutritional Sciences University Of Shizuoka

• Iwasaki Yusaku

  Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka

• Watanabe Tatsuo

  Graduate School of Nutritional and Environmental Sciences, University of Shizuoka

• Tanabe Manabu

  Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shiz

関連論文

• Inhibitory Effects of Capsaicinoids on Fatty Acid Desaturation in a Rat Liver Cell Line(Food & Nutrition Science)
• Adiposity Suppression Effect in Mice Due to Black Pepper and Its Main Pungent Component, Piperine
• Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1
• Activation of TRPV1 and TRPA1 by Black Pepper Components
• Capsaicin-, Resiniferatoxin-, and Olvanil-induced Adrenaline Secretions in Rats via the Vanilloid Receptor(Food & Nutrition Science)
• Quantitative Analysis of Sanshool Compounds in Japanese Pepper (Xanthoxylum piperitum DC.) and Their Pungent Characteristics
• Pungent Qualities of Sanshool-Related Compounds Evaluated by a Sensory Test and Activation of Rat TRPV1
• TRPA1 Agonists—Allyl Isothiocyanate and Cinnamaldehyde—Induce Adrenaline Secretion
• Newly Synthesized Oleylgingerol and Oleylshogaol Activate TRPV1 Ion Channels
• Capsaicinol : Synthesis by Allylic Oxidation and Its Effect on TRPV1-Expressing Cells and Adrenaline Secretion in Rats
• Capsinoid Is Biosynthesized from Phenylalanine and Valine in a Non-Pungent Pepper, Capsicum annuum L. cv. CH-19 Sweet
• Adiposity Suppression Effect in Mice Due to Black Pepper and Its Main Pungent Component, Piperine
• Activation of TRPV1 and TRPA1 by Black Pepper Components
• Galangal Pungent Component, 1'-Acetoxychavicol Acetate, Activates TRPA1
• TRPA1 Agonists-Allyl Isothiocyanate and Cinnamaldehyde-Induce Adrenaline Secretion
• Synthesis of Stable Isotope-Labeled Precursors for the Biosyntheses of Capsaicinoids, Capsinoids, and Capsiconinoids
• TRPV1 Agonist Monoacyglycerol Increases UCP1 Content in Brown Adipose Tissue and Suppresses Accumulation of Visceral Fat in Mice Fed a High-Fat and High-Sucrose Diet
• Synthesis of Stable Isotope-Labeled Precursors for the Biosyntheses of Capsaicinoids, Capsinoids, and Capsiconinoids
• Ingestion of Cinnamaldehyde, a TRPA1 Agonist, Reduces Visceral Fats in Mice Fed a High-Fat and High-Sucrose Diet
• Ingestion of Cinnamaldehyde, a TRPA1 Agonist, Reduces Visceral Fats in Mice Fed a High-Fat and High-Sucrose Diet

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