High-Concentration Cultivation of Lactic Acid Bacteria in Fermentor with Cross-Flow Filtration

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概要

• 論文の詳細を見る

• A new fermentation system with continuous separation of inhibitory metabolites by cross-flow filtration was employed for high-concentration cultivation of homofermentative lactic acid bacteria in order to improve the productivity of cell-mass. The fermentation system allowed continuous removal of lactate, an inhibitory product, while retaining cells completely in the fermentor. By maintaining a low concentration of lactate in the medium, Streptococcus cremoris and Lactobacillus casei were cultivated to high concentrations of 81.5 and 49.0 g-dry cell weight per liter, respectively , giving cell productivities of 19-fold and 9-fold compared with the corresponding conventional batch cultivations. The time course of the cultivation with cross-flow filtration was predicted on the basis of the assumption that specific growth rate can be expressed as a function only of lactate concentration in the medium.

• 公益社団法人日本生物工学会の論文
• 1987-04-25

著者

• Kobayashi Takeshi

  Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University

• Kotani Nobuharu

  Department Of Chemical Engineering Faculty Of Engineering Nagoya University

• Taniguchi Masayuki

  (present Address)department Of Chemical Engineering Faculty Of Engineering Nagoya University

• Kobayashi Takeshi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• KOBAYASHI TAKESHI

  Department of Biotechnology, Faculty of Engineering, Nagoya University

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