Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat
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概要
- 論文の詳細を見る
In this in vivo study, the time course of plasma concentration and the urinary excretion of ethyl α-D-glucoside (α-EG) and ethyl β-D-glucoside (β-EG) were investigated in rats after a single oral dose of 4 mmol/kg body weight. Maximal plasma concentrations of both α-EG and β-EG (EGs) reached approximately 3 mM at 1 h after oral administration and then decreased rapidly. Approximately 80% of EGs administered were excreted into the urine during the first 6 h. Within 24 h, cumulative urinary α-EG and β-EG excretions were estimated to be 87.2±7.9% and 85.4±5.0%, respectively. Traces of both EGs were detected in plasma and urine 24 h after oral ingestion. The results of this study indicate that almost all of both EGs was rapidly absorbed into the blood stream and easily excreted into the urine after oral administration, and that a small amount of them remained in the rat body 24 h after administration.
- 社団法人 日本農芸化学会の論文
- 2008-02-23
著者
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鈴木 徹
岐阜大院・連農・生資科
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SUZUKI Tohru
United Graduate School of Agricultural Science, Gifu University
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Suzuki T
Life Science Research Center Gifu University:faculty Of Applied Biological Sciences Gifu University
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Suzuki Tohru
Life Science Research Center, Gifu University
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So Tomoko
Second Department Of Surgery Faculty Of Medicine University Of Occupational And Environmental Health
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HAYAKAWA Takashi
Faculty of Applied Biological Science, Gifu University
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Sugita Jun
Basic Research Laboratory Kanebo Cosmetics Inc.
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MISHIMA Tomoyuki
Faculty of Applied Biological Sciences, Gifu University
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HARINO Shinpei
Faculty of Agriculture, Gifu University
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NAKAHARA Michio
Basic Research Laboratory, Kanebo Cosmetics, Inc.
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SUZUKI Tohru
Faculty of Applied Biological Sciences, Gifu University
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Suzuki Tohru
United Graduate School Of Agricultural Sci. Gifu Univ.
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Harino Shinpei
Faculty Of Agriculture Gifu University
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Nakahara Michio
Basic Research Laboratory Kanebo Cosmetics Inc.
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Suzuki Tohru
The United Graduate School Of Agricultural Science Gifu University
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Suzuki Tohru
Molecular Genetics Research Center Gifu University
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Suzuki Tohru
United Grad. Sch. Agr. Sci. Gifu Univ.:fac. Appl. Biol. Sci. Gifu Univ.
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Mishima Tomoyuki
School Of Health Science Gifu University Of Medical Science 795-1 Nagamine Ichihiraga Seki Gifu 501-
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University 1-1 Yanagido Gifu Gifu 501-1193 J
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Mishima Tomoyuki
岐阜医療科学大学 保健科学部
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SUZUKI Tohru
The United Graduate School of Agricultural Science, Gifu University
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