Effect of a Sake Concentrate on the Epidermis of Aged Mice and Confirmation of Ethyl α-D-Glucoside as Its Active Component
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概要
- 論文の詳細を見る
Generations of Japanese have appreciated the positive effects that sake can have on skin conditions, and studies have shown that concentrated sake suppressed the epidermal barrier disruption caused by ultraviolet B (UVB) irradiation. We investigated the effect of a topical application of a sake concentrate on the murine epidermis and found that the intercellular lipid content in an aged epidermis was significantly increased. Furthermore, the topical application of ethyl α-D-glucoside (α-EG), a component of sake, brought about a similar improvement in the levels of intercellular lipids. Following on from this, we confirmed that α-EG also significantly increased the content of loricrin protein, an indicator of successful corneocyte differentiation, while reducing the number of corneocyte layers in the aged stratum corneum. These results confirmed α-EG as the primary active component of the sake concentrate that had a positive effect on the epidermis. α-EG increased the intercellular lipid content, accelerated the differentiation of corneocytes, and reduced the thickness, thus improving the functions of the stratum corneum.
- 2007-02-23
著者
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HAYAKAWA Takashi
Faculty of Applied Biological Science, Gifu University
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MISHIMA Tomoyuki
Faculty of Applied Biological Sciences, Gifu University
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NAKAHARA Michio
Basic Research Laboratory, Kanebo Cosmetics, Inc.
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NAKAHARA Michio
Faculty of Applied Biological Sciences, Gifu University
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Nakahara Michio
Basic Research Laboratory Kanebo Cosmetics Inc.
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Mishima Tomoyuki
School Of Health Science Gifu University Of Medical Science 795-1 Nagamine Ichihiraga Seki Gifu 501-
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University 1-1 Yanagido Gifu Gifu 501-1193 J
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Mishima Tomoyuki
岐阜医療科学大学 保健科学部
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