Effect of Vitamin B_6 Deficiency on an Antibody Production in Mice

概要

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To investigate the effects of vitamin B_6 (B_6) deficiency on an antibody production in BALB/c mice, the production of specific immunoglobulin (Ig) E antibody against dinitrophenylated ovalbumin (DNP-OVA) were measured by the methods of enzyme linked immunosorbent assay. The mice fed on on a B_6 deficient diet for 4 weeks were immunized intraperitoneally with DNP-OVA absorbed to aluminum hydroxide gel. The contents of anti DNP-IgE antibodies in sera of B_6 deficient mice significantly increased compared to that of control mice fed on a diet containing B_6. In addition, Interleukin-4, which was known to induce IgE production in allergic reactions from splenocytes of B_6 deficient mice, was approximately four-fold higher than that in control mice. According to the recovery test to the B_6 deficient mice, that is feeding the control diet for 21 days, all values in terms of the body, thymus, and spleen weight, total serum protein, IgG, and anti DNP-IgE content, regained almost the same levels as those of control. These results suggest that B_6 deficiency in mice would have relation to the stimulation of specific IgE antibody production against DNP-OVA.
社団法人日本農芸化学会の論文
1997-08-23