Effect of Vitamin B_6 Deficiency on Linoleic Acid Desaturation in the Arachidonic Acid Biosynthesis of Rat Liver Microsomes
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概要
- 論文の詳細を見る
The effect of vitamin B_6 deticiency on the desaturation of linoleic acid (18 : 2n-6) to γ-linolenic acid (18 : 3n-6) in rat liver microsomes was studied. Rats fed with a vitamin B_6-deficient 70% casein diet for 5weeks displayed a striking decrease mainly in the activity of terminal darutaΔ6-desaturase in the 18 : 2n-6desaturation system, although the activity of the electron-transport enzyme, NADH-cytochrome b_5 reductase, was also significantly decreased. The 18 : 2n-6 desaturation index, the arachidonic acid (20 : 4n-6)/18 : 2n-6 ratio in the liver microsomal total lipids and in their phosphatidylcholine (PC) fraction, decreased together with the microsomal A6-desaturase activity, these changes being quite faithfully reflected in the plasma lipid. Among the microsomal lipid components, the PC content signiticantly decreased. In addition,a highly positive correlation was found between the PC content and Δ6-desaturase activity in liver microsomes. In an in vitro experiment, the Δ6-desaturase activity decreased linearly with increasing rate of PC hydrolysis by phospholipase C. These results suggest that the altered PC content in microsomes induced by vitamin B_6 deticiency in vivo may affect the 18 : 2n-6 desaturation and thus decrease the biosynthesis of 20 : 4n-6.
- 社団法人日本農芸化学会の論文
- 1994-03-23
著者
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She Q‐b
Gifu Univ. Gifu Jpn
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She Qing-Bai
The United Graduate School of Agricultural Science, Gifu University
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Hayakawa Takashi
The United Graduate School of Agricultural Science, Gifu University
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She Qing-bai
The United Graduate School Of Agricultural Science Gifu University
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Hayakawa T
Gifu Univ. Gifu Jpn
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University 1-1 Yanagido Gifu Gifu 501-1193 J
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Hayakawa Takashi
The United Graduate School Of Agricultural Science Gifu University
関連論文
- Effect of Vitamin B_6 Deficiency on Linoleic Acid Desaturation in the Arachidonic Acid Biosynthesis of Rat Liver Microsomes
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